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These abnormal blood vessels leak fluid and blood into and beneath the retina, causing vision loss.Although the underlying molecular causes of wet AMD are not completely known, VEGF is known to play a central role in the growth of new blood vessels in wet AMD.We are advancing a pipeline of gene therapy product candidates targeting the treatment of ocular diseases.Diabetic macular edema (DME) is a vision-threatening complication of DR that can occur at any severity stage of DR. DME is characterized by retinal thickening in the area of the macula, and the risk of DME increases with the worsening of the DR severity score (DRSS). Adverum Biotechnologies (ADVM) has been upgraded to a Zacks Rank 2 (Buy), reflecting growing optimism about the company's earnings prospects. With the recent approval of our investigational new drug application for ADVM-022, we have initiated INFINITY in DME, a high-need subgroup of patients within the larger DR population. DME affects approximately 5% of people with diabetes and is the most common cause of vision loss in people with diabetic retinopathy (DR). The stock traded as high as $25.50 and last traded at $25.50, with a volume of 61112 shares traded. The incidence of new cases of wet AMD in the U.S. is approximately 150,000 to 200,000 annually, and this number is expected to grow significantly as the country’s population ages 2,3. Adverum Biotechnologies Q1 2020 Conference Call May 28, 2020 at 1:30 PM PDT Adverum Biotechnologies announced the initiation of INFINITY, a phase 2, multicenter, randomized, double-masked, active comparator-controlled trial to assess a single intravitreal (IVT) injection of ADVM-022 in patients with diabetic macular edema (DME). Adverum Biotechnologies Announces New INFINITY Phase 2 Trial for ADVM-022 in Diabetic Macular Edema, Reports Recent Business Progress and First Quarter 2020 Financial Results Additional objectives include assessments of treatment burden, visual acuity, retinal anatomy and safety outcomes.Participants in this double-masked trial will be randomized to one of three arms for their study eye treatment:Adverum Biotechnologies announced the initiation of INFINITY, a phase 2,  multicenter, randomized, double-masked, active comparator-controlled trial to assess a single intravitreal (IVT) injection of ADVM-022 in patients with diabetic macular edema (DME).
In patients with wet AMD, an aggressive form of AMD, abnormal blood vessels grow underneath and into the retina. Although the underlying molecular causes of wet AMD are not completely known, VEGF is known to play a central role in the growth of new blood vessels in wet AMD. This … INFINITY has been designed to provide robust, controlled data on ADVM-022 in DME and will be conducted at trial sites across the United States.”The INFINITY trial will enroll approximately 33 patients and is designed to demonstrate superior control of disease activity following a single IVT injection of ADVM-022 compared to a single aflibercept injection, as measured by time to worsening of DME disease activity. Additionally, we look forward to presenting data from all four cohorts of the OPTIC phase 1 trial for ADVM-022 in wet AMD by the end of this year.”Aaron Osborne, MBBS, chief medical officer of Adverum Biotechnologies stated, “Over 30 million people are impacted by diabetes in the United States. The company also reported financial results for the first quarter ended March 31, 2020 and provided a corporate update.© 2020 Bryn Mawr Communications, LLC. The company is targeting unmet medical needs for serious ocular and rare diseases. These are effective but typically require frequent and long-term injections for patients to maintain good vision. “We continue to execute on our goal to develop and commercialize our novel gene therapy candidate ADVM-022 as a potential one-time treatment for patients with wet age-related macular degeneration (AMD) and DME, the two largest indications for anti-VEGF treatment. Featured Upcoming Events. Compliance with these regimens can be difficult for patients, leading to undertreatment and vision loss. Presentation for KOL Discussion of New Clinical Data from OPTIC Phase 1 Trial. “I’m thankful for the strong commitment and resilience our employees have exhibited towards advancing our pipeline despite the challenges of COVID 19,” Leone Patterson, president and chief executive officer, Adverum Biotechnologies, said in a company news release. Chardan Capital […] Adverum Biotechnologies Inc (NASDAQ:ADVM)’s stock price reached a new 52-week high during mid-day trading on Monday . We believe that the exciting data seen to date for ADVM-022 in the ongoing OPTIC trial in wet AMD highlight this therapy’s transformative potential to deliver long-term control of serious retinal vascular diseases, including DME. DME affects approximately 5% of people with diabetes and is the leading cause of vision loss in patients with DR.The current standard-of-care therapy for DME is anti-VEGF intravitreal injections. Adverum will match your 401 (k) contributions dollar for dollar up to 3% of your annual salary and 50 cents on the dollar for the next 2% of salary.
... Adverum Biotechnologies Q1 2020 Conference Call. There are currently no events to display. Employee Stock Purchase Plan Adverum offers a … The stock had previously closed at $24.63. Employees are eligible to contribute up to the IRS-regulated annual amount. A number of research firms recently weighed in on ADVM.